Drug Interactions With Eprosartan/HCTZ

Diabetes Medications
Using eprosartan/HCTZ with medications used to treat diabetes may increase blood sugar levels. If you take these medications together, your healthcare provider may monitor you more closely and may need to adjust the dose of your diabetic medication.
 
Dofetilide
Taking dofetilide with hydrochlorothiazide may cause a potentially dangerous abnormal heart rhythm called QT prolongation. The manufacturer of dofetilide recommends that these medications not be taken together.
 
Eplerenone
If you take eprosartan/HCTZ with eplerenone, the level of potassium in your blood may become too high. Your healthcare provider may choose to monitor your blood potassium level if you take these medications together.
 
Lithium
Eprosartan/HCTZ may increase blood lithium levels, potentially causing lithium toxicity. Your healthcare provider may choose to monitor your blood lithium levels when you first start eprosartan/HCTZ. You may need a lower lithium dosage. Contact your healthcare provider right away if you have symptoms of toxicity, such as confusion, tremors, or coordination problems, while taking these medications together.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Eprosartan/HCTZ can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are dehydrated, taking NSAIDs and eprosartan/HCTZ together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
  
Other Blood Pressure Medications
When taking eprosartan/HCTZ with another high blood pressure medication, your blood pressure may decrease too much. Your healthcare provider may monitor your blood pressure more closely and change the dose of one of your medications if your blood pressure becomes too low.
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Eprosartan/HCTZ Drug Information

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