Enalapril Drug Interactions

Enalapril Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when enalapril is combined with any of the drugs listed above.
 
Diuretics
When taking enalapril with a diuretic, your blood pressure may decrease too much. This is more likely to occur when you first start taking enalapril. In order to decrease the chances of this interaction, your healthcare provider may:
 
  • Change the dosages of either medicine
  • Start you on a lower dose of enalapril
  • Monitor you more closely.
     
Injectable Gold
Reactions have been reported in people taking enalapril who received gold injections. These reactions included symptoms such as facial flushing, nausea, vomiting, and low blood pressure.
 
Lithium
Enalapril may increase the risk of lithium toxicity and may increase the lithium levels in the blood. Your healthcare provider may choose to monitor your blood lithium levels more frequently and may need to adjust your lithium dosage.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
If you have kidney disease or kidney failure, taking both NSAIDs and enalapril may add to the damage that your kidneys are already suffering. Also, NSAIDs may decrease the blood pressure-lowering effects of enalapril. Talk to your healthcare provider about the possible risks of using NSAIDs and enalapril together in your particular situation.
 
Potassium-Containing Products
If you are taking a potassium product and enalapril, the levels of potassium in your blood may become too high. This can cause serious problems. Talk to your healthcare provider about possible interactions that may occur when using potassium and enalapril together in your situation.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
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