Enalapril and Depression

Several possible side effects may occur with enalapril, and depression appears to be a rare complaint among those taking the medication. In clinical studies, less than 1 percent of people taking enalapril reported experiencing depression. In such cases, it is difficult to determine whether the depression in question is a result of other factors or the enalapril. Depression can lead to many possible symptoms, and it may help people to be aware of these symptoms so they can correctly identify them and get treatment if necessary.

Is Depression an Enalapril Side Effect?

There are several possible side effects that may develop in people taking enalapril (available as Vasotec® and generic Enalapril Maleate). Depression appears to be a rare complaint in people taking enalapril. In clinical studies, depression was reported in less than 1 percent of people who took enalapril. Given how common depression is in the general population and how rare a complaint it is in people who take enalapril, it is difficult to say whether depression is caused by the medicine, specific factors, or a combination of factors.

Enalapril and Depression: What to Look For

While depression may not be a commonly reported side effect of enalapril, it is extremely common in society today. In fact, in any given one-year period, 9.5 percent of the population (about 18.8 million American adults) suffer from depression. Therefore, knowing the symptoms of depression can be helpful.
Possible depression symptoms may include:
  • Persistent sad, anxious, or "empty" mood
  • Feelings of hopelessness and pessimism
  • Feelings of guilt, worthlessness, and helplessness
  • Loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex
  • Decreased energy, fatigue, and being "slowed down"
  • Difficulty concentrating, remembering, and making decisions
  • Insomnia, early-morning awakening, or oversleeping
  • Appetite and/or weight loss, or overeating and weight gain
  • Thoughts of death or suicide; suicide attempts
  • Restlessness and irritability
  • Persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders, and chronic pain.
Keep in mind that there are other conditions that can share similar symptoms with depression.
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Enalapril Medication

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