Lithium (Eskalith, Lithane, Lithonate, Lithotabs)
Diovan HCT may increase the
lithium levels in your blood. For this reason, it is generally not recommended that the medications be combined. However, they can be taken together in certain situations, especially if your lithium levels are carefully monitored.
Narcotics
When taking
Diovan HCT with a narcotic, your
blood pressure may decrease too much. In order to decrease the chances of this interaction, your healthcare provider may change the dose of either medicine, start you on a lower dose of Diovan HCT, and/or monitor you more closely.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Diovan HCT can interact with
NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have
congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and Diovan HCT together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
Other Blood Pressure Medicines
When taking Diovan HCT with another
high blood pressure medication, your blood pressure may decrease too much. In order to minimize the chances of this Diovan HCT interaction, your healthcare provider may monitor you more closely and/or change the dose of either medicine.
Potassium-Sparing Diuretics
The
valsartan component of Diovan HCT has a tendency to increase potassium levels in the blood. With Diovan HCT, however, this effect is usually nicely counteracted by the tendency of the other component (
hydrochlorothiazide) to lower potassium levels.
Nonetheless, it is possible that combining Diovan HCT with potassium-sparing diuretics (which usually increase blood potassium) could lead to dangerously high potassium levels in the blood. If you take such medications together, your healthcare provider should closely monitor your blood potassium levels.
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