More Detail on Interactions With Cozaar
The following sections explain in detail the potentially negative interactions that can occur when
Cozaar is combined with any of the drugs listed above.
ACE Inhibitors
Although not an ACE inhibitor, Cozaar works similarly to ACE inhibitors. Thus, combining such drugs may increase the risk of high potassium levels (hyperkalemia), kidney failure, and dangerously low
blood pressure. Careful monitoring is necessary for such combinations.
Diuretics
When you are taking Cozaar with a diuretic, your blood pressure may decrease too much. This is more likely to occur when Cozaar is first started. In order to decrease the chances of this Cozaar interaction, your healthcare provider may change the dosages of either medicine, start you on a lower dose of Cozaar, and/or monitor you more closely.
Potassium Supplements or Salt Substitutes With Potassium
If you are taking Cozaar with a potassium supplement or a salt substitute with potassium, the levels of potassium in your blood may become too high. This can cause serious problems. For your particular situation, talk to your healthcare provider about using potassium and Cozaar together.
Potassium-Sparing Diuretics
If you are taking both Cozaar and a potassium-sparing diuretic, your body may metabolize them differently than intended and increase the levels of potassium in your blood. Your healthcare provider may choose to monitor your progress more closely.
Rifampin (Rifadin, Rimactane, Rofact)
If you are taking Cozaar and rifampin together, your body may metabolize Cozaar differently than intended. This can cause a decreased level of Cozaar in your body. When using these medicines together, your healthcare provider may choose to monitor you more closely and adjust your Cozaar dose as needed.
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