Coreg and Depression

Side effects may develop with the use of Coreg, and depression is seen in less than 1 percent of patients. However, because depression is so common in the general population, it is unclear whether Coreg causes depression. If you are taking Coreg and depression symptoms occur, notify your healthcare provider immediately; he or she may consider another medicine to treat your condition.

 

Coreg and Depression: An Overview

Coreg® (carvedilol) is a prescription medicine used to treat high blood pressure or congestive heart failure, as well as to improve survival following a heart attack. It is part of a class of medicines called beta blockers. As with all medicines, side effects are possible with Coreg, and depression is one of these side effects.
 
Depression is a complaint that is reported rarely (less than 1 percent) in people taking Coreg. This data comes from clinical trials that studied the drug in thousands of people and documented the side effects. The challenge with Coreg and depression is that given how uncommon depression is reported with Coreg and how common it is within the general population, it is difficult to tell whether the condition is caused by Coreg, other factors, or a combination of both.
 

Coreg and Depression: What Does Other Research Say?

Little research has been done looking specifically at whether Coreg can cause depression or make it worse.
 Several studies, however, have looked at depression and beta blockers. The title of one research study published by Ried and colleagues probably most ably states what the literature says overall about depression and beta blockers: "Beta Blockers and Depression: The More the Murkier?" The fact is that despite a lot of research in this area, healthcare providers cannot say with certainty that beta blockers, including Coreg, cause depression. They also cannot say with certainty that beta blockers do not cause depression.
 
(Coreg and Depression Continued: Page 2)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;