Bystolic Interactions

The following sections explain in detail the potentially negative interactions that can occur when Bystolic is combined with any of the drugs listed above.

 

Combining Bystolic with certain arrhythmia medications may cause a dangerously slow heart rate (bradycardia). You may need to be monitored closely if you take these medications together. In some cases, Bystolic should not be combined with an arrhythmia medication.

 

Taking Bystolic with certain calcium channel blockers may cause a dangerously slow heart rate (bradycardia). You may need to be monitored more closely if you take these medications together. In some cases, Bystolic should not be combined with a calcium channel blocker.

 

If you take both clonidine and Bystolic, stopping clonidine (without stopping Bystolic) could increase the risk of dangerously high blood pressure, strokes, and other serious problems. People are typically advised to stop taking Bystolic several days before gradually reducing the clonidine dosage. Do not attempt this without the approval and supervision of your healthcare provider.

 

Bystolic is metabolized by a specific liver enzyme known as CYP 2D6. Some other medications (known as CYP 2D6 inhibitors) slow down the activity of this enzyme, causing an increase in the level of Bystolic in the blood. This could potentially lead to serious Bystolic side effects. Different medications inhibit the enzyme to different extents; some interactions may be minor, while others may be quite severe. Check with your healthcare provider before combining Bystolic with a CYP 2D6 inhibitor.

 

Combining Bystolic with digoxin may cause a dangerously slow heart rate (bradycardia). You may need to be monitored more closely if you take these medications together. In some cases, Bystolic should not be taken with digoxin.