Drug Interactions With Bisoprolol and Hydrochlorothiazide

Clonidine
If you take clonidine with bisoprolol and hydrochlorothiazide, stopping clonidine (without stopping bisoprolol and hydrochlorothiazide) could increase the risk of dangerously high blood pressure, strokes, and other serious problems. People are typically advised to stop taking bisoprolol and hydrochlorothiazide several days before gradually reducing the dose of clonidine. Do not attempt this without the approval and supervision of your healthcare provider.
 
Corticosteroids
Corticosteroids can increase the risk of low potassium levels (hypokalemia) when taking with bisoprolol and hydrochlorothiazide, which can be dangerous. Your healthcare provider may need to monitor your potassium levels more closely if this drug interaction is a concern.
 
Diabetes Medications
The hydrochlorothiazide component of bisoprolol and hydrochlorothiazide may increase the risk of high blood sugar (hyperglycemia), while the bisoprolol component may mask the symptoms of low blood sugar (hypoglycemia). Your healthcare provider may recommend that you monitor your blood sugar more closely, especially when you start or stop taking bisoprolol and hydrochlorothiazide, or even when you change your dose.
 
Digoxin
Combining bisoprolol and hydrochlorothiazide with digoxin may cause a dangerously slow heart rate (bradycardia). You may need to be monitored closely if you take these medications together. In some cases, bisoprolol and hydrochlorothiazide should not be taken with digoxin.
 
Lithium
Taking hydrochlorothiazide (one of the active ingredients in bisoprolol and hydrochlorothiazide) with lithium may increase the level of lithium in your blood, increasing your chance of side effects. In general, lithium should not be taken with diuretics, including hydrochlorothiazide. Your healthcare provider may need to monitor your lithium level more closely and adjust your dosage as necessary.
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Bisoprolol and Hydrochlorothiazide Information

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