Avapro Precautions and Warnings

Before starting treatment with Avapro, precautions and warnings for the medicine should be fully understood. Talk to your healthcare provider if you have kidney disease or kidney failure, heart disease, or any allergies. Avapro precautions and warnings also extend to possible side effects, such as extreme low blood pressure, decreased kidney function, and, in those who are taking potassium supplements, excessive potassium levels in the blood.

Avapro: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Avapro® (irbesartan) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or trying to become pregnant
  • On dialysis
  • Breastfeeding.
Tell your healthcare provider about all other medicines you are currently taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Avapro Precautions and Warnings

Some Avapro warnings and precautions to be aware of include:
  • There are a couple of medicines that Avapro can interact with (see Avapro Interactions).
  • Avapro may cause extreme low blood pressure in some people. This is more likely to happen in people who are taking a diuretic, are on dialysis, have diarrhea or vomiting, sweat a lot, or have congestive heart failure. This is why it is important to drink fluids regularly while taking Avapro. If you have any possible symptoms of low blood pressure, such as dizziness, lightheadedness, or fainting, contact your healthcare provider. If you have fainted, stop taking Avapro until you have talked to your healthcare provider.
  • Make sure not to drive, operate any heavy machinery, or perform any other tasks that require alertness before you know how Avapro affects you.
  • Avapro is a pregnancy Category C medicine for the first trimester and a pregnancy Category D medicine for the second and third trimesters, meaning that Avapro has health risks to your unborn child. If you become pregnant while taking Avapro, contact your healthcare provider immediately (see Avapro and Pregnancy for more information).
  • While taking Avapro, do not use potassium supplements or salt substitutes with potassium, unless you have discussed this with your doctor. This is because in some people taking Avapro, potassium in the blood can increase to dangerous levels.
  • This medication may cause a decrease in kidney function, especially in people who are elderly, have kidney disease, have severe congestive heart failure (CHF), or are taking nonsteroidal anti-inflammatory drugs (NSAIDs) or diuretics (water pills). Your healthcare provider may choose to monitor your kidney function with a blood test while you are taking it. Contact your healthcare provider if you notice a decrease in urination or swelling in your hands, legs, ankles, or feet, which can be signs of kidney problems.


  • If you are nursing, it is not known whether Avapro passes through your milk. Therefore, if you are nursing, talk with your healthcare provider about whether you should stop Avapro or discontinue breastfeeding.
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