Avapro and Depression

Certain side effects may develop with the use of Avapro, and depression is a rare but possible side effect that occurs in less than 1 percent of patients. However, since depression is so common in the general population, it is unclear whether Avapro actually causes the condition. If you are taking Avapro and depression symptoms occur, your healthcare provider may recommend another medicine to treat your condition.

Avapro and Depression: An Overview

Avapro® (irbesartan) is a prescription medicine used to treat high blood pressure or diabetic nephropathy. It is part of a class of medicines called angiotensin II receptor blockers. As with all medicines, there are several possible side effects that can occur in people taking Avapro. One of these possible side effects is depression.
However, depression is rarely reported (less than 1 percent) in people taking Avapro. This data comes from clinical trials that studied the drug extensively in thousands of people and documented its side effects. The challenge with Avapro and depression is that given how uncommon depression is reported with Avapro yet how common it is within the general population, it is difficult to tell whether depression is caused by Avapro, other factors, or a combination of both.

Avapro and Depression: What to Look For

While depression may not be a commonly reported side effect of Avapro, it is extremely common in society today. In fact, in any given one-year period, 9.5 percent of the population (about 18.8 million American adults) suffer from depression. Therefore, knowing the symptoms of depression can be helpful.
Possible symptoms may include:
  • Persistent sad, anxious, or "empty" mood
  • Feelings of hopelessness and pessimism
  • Feelings of guilt, worthlessness, and helplessness
  • Loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex
  • Decreased energy, fatigue, and being "slowed down"
  • Difficulty concentrating, remembering, and making decisions
  • Insomnia, early-morning awakening, or oversleeping
  • Appetite and/or weight loss; overeating and weight gain
  • Thoughts of death or suicide; suicide attempts
  • Restlessness and irritability
  • Persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders, and chronic pain.
Keep in mind that other conditions can share similar symptoms with depression.
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