Avalide and Pregnancy
Pregnancy Risks With AvalideIrbesartan, one of the medications in Avalide, belongs to a class of drugs called angiotensin II receptor blockers (ARBs). When taken by pregnant women in the second and third trimesters, ARBs have been reported to cause serious problems in the developing fetus and newborn.
Some of the reported problems have included:
- Kidney problems, including kidney failure
- Low blood pressure
- Skull deformity
- Poor growth of the fetus
- Premature birth
- Heart problems.
In addition, Avalide may cause low levels of amniotic fluid. Low amniotic fluid levels can lead to further problems in the developing fetus, such as incomplete lung development and deformities of the head and face.
Although these problems have not been reported with the use of ARBs in the first trimester, it is generally recommended that an ARB medication be stopped as soon as a woman becomes pregnant.
Hydrochlorothiazide, the other drug in Avalide, may also cause problems in the fetus or newborn infant, including:
- Jaundice (yellowing of the skin or whites of the eyes)
- Decrease in the number of platelets in the blood (thrombocytopenia)
- Low blood sugar (hypoglycemia)
- Blood electrolyte problems, such as low sodium (hyponatremia) or low potassium (hypokalemia).
There may be very rare instances when Avalide use is necessary during pregnancy. In these cases, the level of amniotic fluid should be monitored regularly. If amniotic fluid levels become low, a decision to continue or stop Avalide should be made based on the mother's individual situation. It is recommended that newborns exposed to Avalide in utero be monitored for kidney problems, low blood pressure, and high blood potassium levels.