Drug Interactions With Aliskiren-HCTZ

Lithium (Eskalith, Lithobid)
Taking hydrochlorothiazide (one of the components of aliskiren-HCTZ) with lithium may increase the level of lithium in your blood, possibly increasing your chance of side effects. People are typically not advised to take lithium with diuretics, including hydrochlorothiazide. If you do take these medications together, your healthcare provider may need to monitor your lithium level more closely and/or change your lithium dose.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Aliskiren-HCTZ can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are dehydrated, taking NSAIDs and aliskiren-HCTZ together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
  
Potassium-Containing Products
Combining aliskiren-HCTZ with potassium products may increase your risk of high blood potassium (hyperkalemia), which can be a serious problem. If you take these substances together, your healthcare provider should monitor your potassium levels.
 
Spironolactone Products (Aldactone, Aldactazide)
Taking aliskiren-HCTZ with spironolactone may increase your risk of high blood potassium (hyperkalemia), which can be a serious problem. If you take these medications together, your healthcare provider should monitor your potassium levels.
 
Triamterene Products (Dyrenium, Dyazide, Maxzide)
Combining aliskiren-HCTZ with triamterene may increase your risk of high blood potassium (hyperkalemia), which can be a serious problem. If you take these medications together, your healthcare provider should monitor your potassium levels.
 
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Information on Aliskiren-HCTZ

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