Accupril

The prescription drug Accupril is licensed to treat several conditions related to the heart and blood vessels, including high blood pressure and symptoms of congestive heart failure. The drug lowers blood pressure by blocking an enzyme in the body that causes blood vessels to constrict. Accupril comes as a tablet and is taken once or twice daily. Possible side effects include headache, fatigue, and cough.

What Is Accupril?

Accupril® (quinapril hydrochloride) is a prescription medicine that has been licensed to treat several conditions related to the heart and blood vessels. It is part of a class of drugs called angiotensin-converting enzyme inhibitors, or ACE inhibitors for short.
 

Who Makes Accupril?

It is manufactured by Pfizer Pharmaceuticals.
 

What Is It Used For?

Accupril has been licensed to treat a number of conditions. These uses include:
 
Accupril does not cure high blood pressure or congestive heart failure, and has not been approved for use in children.
 
(Click What Is Accupril Used For? for more information on what it is used for, including possible off-label uses.)
 

How Does It Work?

Accupril is part of a class of drugs called ACE inhibitors.
 ACE stands for angiotensin-converting enzyme. Accupril helps to block the angiotensin-converting enzyme, which is normally part of a reaction in the body that causes the blood vessels to narrow (constrict). By blocking this enzyme, the medication causes blood vessels to relax, which can lower blood pressure.
 
By helping blood vessels relax, Accupril also increases the efficiency of the heart. This means that the heart does not have to work as hard and more blood can be pumped out to the rest of the body. Both of these are helpful for a person with congestive heart failure.
 

Effects

A blood pressure reading consists of two numbers -- for example, 120/80. The top number is known as the systolic blood pressure, and the bottom number is the diastolic blood pressure. During clinical studies in people taking Accupril, systolic blood pressure (the top number) decreased on average by 5 to 11 mmHg and diastolic blood pressure (the bottom number) decreased by 3 to 7 mmHg on average. The higher the dose of Accupril, the greater the drop in blood pressure tended to be. By lowering blood pressure, Accupril can decrease the risks that accompany long-term high blood pressure (see Effects of High Blood Pressure).
 
For people with congestive heart failure, the effects of Accupril on the heart and blood vessels cause a decrease in the symptoms of congestive heart failure, including shortness of breath, fatigue, and swelling. These effects can also improve a person's exercise tolerance.
 

When and How Do I Take It?

Some general considerations for when and how to take Accupril include:
 
  • The medication comes in tablet form. It is usually taken once or twice a day.
  • It should be taken on an empty stomach -- at least one hour before or two hours after a meal.  
  • It should be taken at the same times each day to maintain an even level of Accupril in your blood.
  • For the medication to work properly, you have to take it as prescribed. It will not work if you stop taking it.
     

Dosing

The dosage your healthcare provider recommends will vary depending on a number of factors, including:
 
  • Your age
  • The medical condition being treated
  • Other medical conditions you may have
  • Other medications you may be currently taking.
     
As with any medication, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 
(Click Accupril Dosage for more information.)
 

Side Effects

As with any medicine, there are possible side effects with Accupril. However, not everyone who takes it will experience side effects. When side effects do occur, they are often minor, meaning that they require no treatment or are easily treated by you or your healthcare provider. Serious side effects are less common.
 
The most common Accupril side effects seen in people with high blood pressure include:
 
In people with congestive heart failure, the most common side effects include:
 
(Click Accupril Side Effects to learn about the specific side effects of this drug, including serious side effects to look out for. You can also read about other possible side effects by going to:
 

Drug Interactions With Accupril

Accupril can potentially interact with a number of medicines.
 
(Click Accupril Drug Interactions for more information.)
 

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking this medication if you have:
 
Also, let your healthcare provider know if you:
 
  • Are pregnant or trying to become pregnant (see Accupril and Pregnancy)
  • Are breastfeeding
  • Are on dialysis
  • Will be undergoing surgery or anesthesia.
     
Tell your healthcare provider about all the medicines you are currently taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
Do not take any potassium supplements or salt substitutes containing potassium without first discussing it with your healthcare provider.
 
(Click Accupril Precautions and Warnings for more information on this topic, including information on who should not take this drug.)
 

Overdose

People who take too much Accupril may have overdose symptoms that could include extremely low blood pressure.
 
If you happen to overdose, seek medical attention immediately.
 
(Click Accupril Overdose for more information.)
 

Storage Methods

The medication should be stored at room temperature, and away from moisture and heat. Accupril tablets should be kept in an airtight container.
 
Keep Accupril and all medications out of the reach of children.
 

What Should I Do If I Miss a Dose of Accupril?

If you do not take your dose as scheduled, take your next dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed one and continue with normal dosing. Never take a double dose!
 

Strengths

Accupril tablets are available in several strengths, including:
 
  • Accupril 5 mg
  • Accupril 10 mg
  • Accupril 20 mg
  • Accupril 40 mg.
     

Generic Accupril

Accupril is available as a generic medicine.
 
(Click Generic Accupril for more information.)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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