Accupril drug interactions can alter the levels of certain drugs in your blood and cause your body to metabolize the drugs differently than intended. Among the drugs that Accupril can potentially interact with are potassium-sparing diuretics like amiloride, triamterene, and spironolactone; diuretics like torsemide, hydrochlorothiazide, and furosemide; and nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, nabumetone, and diclofenac.